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System at a Glance
| Our Score | 9.90 / 10 (#1 for Glutathione) |
|---|---|
| Best For | The cheapest first month with supplies included |
| Price | $69 first month, then $133/mo |
| Supply | 2,000mg injectable glutathione monthly |
| Included | Injection supplies |
| Shipping | 2-day, temperature-controlled |
| Extra | 20% off a Rythm blood test |
| Our Rank | #1 in glutathione providers |
What Is System?
System is an online provider of compounded glutathione, and it is #1 in our best glutathione providers ranking. It wins on entry price and completeness: $69 for the first month, a full 2,000mg monthly supply, and the injection supplies in the box, so there is nothing extra to order.
Glutathione is made of three amino acids (glutamate, cysteine and glycine) and is the body’s main internal antioxidant. It helps neutralise reactive oxygen species and supports the liver’s processing of drugs and toxins. Levels tend to fall with age, illness and heavy alcohol use.
The evidence needs honest framing. Research on glutathione supplementation is mixed and mostly small: some studies raise glutathione stores, few show clear clinical outcomes, and claims about skin lightening in particular are not well supported. Users commonly report more energy and better skin appearance, which are reports, not proven effects.
Pros & Cons
Pros
- $69 first month, down from $133
- 2,000mg monthly injectable supply
- Injection supplies included
- 20% off a Rythm blood test
- Fully online, no clinic visit
Cons
- Price rises to $133/month after the first month
- Compounded glutathione, not an FDA-approved finished product
- Evidence for injectable glutathione is mixed
How System Works
Online request
Complete an online assessment. System is fully online, so there is no clinic visit.
Clinician review
A licensed clinician reviews your history before any prescription. Approval is not guaranteed.
Temperature-controlled delivery
Your 2,000mg injectable supply ships in 2 days in temperature-controlled packaging, with injection supplies included.
Optional lab testing
System offers 20% off a Rythm blood test if you want to track your own biomarkers alongside treatment.
Safety & What to Know
Reported side effects of glutathione injections include injection-site pain or bruising, and rare allergic reactions or rash. Rotate injection sites and stop if you develop hives, swelling or trouble breathing.
System’s glutathione is compounded, so it is not an FDA-approved finished product, and the FDA does not review compounded drugs for quality before they reach you. Ask which pharmacy fills your order.
Tell the clinician about all medications, allergies and conditions, and talk to your own doctor first if you are pregnant or breastfeeding. Glutathione is not a treatment for any disease.
System Pricing
| First month | $69 |
|---|---|
| Standard price | $133/month |
| Monthly supply | 2,000mg injectable |
| Injection supplies | Included |
| Blood test | 20% off Rythm |
The $69 price is a first-month offer, and the price rises to $133 a month afterwards. Budget for $133 when comparing providers, and confirm the renewal price at checkout before you pay.
Who System Is For
A good fit if you
- Want the lowest-cost first month to try glutathione
- Prefer everything, supplies included, in one box
- Want a fully online process
- Understand that the evidence is mixed and the product is compounded
Look elsewhere if you
- Want a needle-free format such as a nasal spray or patch
- Want the lowest ongoing monthly price
- Want lab-guided dosing built in
How System Compares
System’s $133 renewal is higher than the $69 a month that Joi + Blokes and PlexusDx advertise, and Embody charges a flat $99. AgelessRx offers injection, nasal spray or a needle-free patch, and Hone Health adds lab monitoring from $99 a month. Taurus is cheaper than System at first at $79 but renews at $179. Glutathione is often paired with NAD+, and our DirectMeds NAD+ review covers that option. For another longevity choice, see sermorelin.
System FAQ
$69 for the first month, then $133 a month. Each monthly supply is 2,000mg of injectable glutathione with supplies included.
No. It is compounded, so it is not an FDA-approved finished product.
Yes. Supplies come in the box, so there is nothing extra to order.
Two-day shipping in temperature-controlled packaging. There is no clinic visit.
The evidence for skin lightening is not well supported, so do not buy it for that reason.
System sells injections. AgelessRx offers a nasal spray and a patch.
Our Verdict
9.90 / 10 · Outstanding
System is the easiest, cheapest way to try injectable glutathione: $69 for the first month, a full 2,000mg supply and supplies included. The trade-offs are a renewal price almost double the intro offer, a compounded product and evidence that is mixed at best. If you want to test it cheaply, start here; if you plan to stay, compare the $133 renewal with cheaper ongoing rates elsewhere.
See the full Best Glutathione Providers ranking →About the author
Written by the TreatmentPick Editorial Team, a non-clinical research team that compares online treatment providers using only what each provider publishes. Facts were last checked on 2026-11-15. See how we review.